Gene information
Official symbol KCNH2
Official full name potassium voltage-gated channel subfamily H member 2
Gene type protein-coding gene
Chromosome7q36.1
Alias symbolKv11.1; HERG; erg1
Previous symbolLQT2
Gene familyPotassium voltage-gated channels
Resources
Entrez Gene 3757
HGNC HGNC:6251
Ensembl ENSG00000055118
Vega OTTHUMG00000158341
UCSC uc003wic.4
GO terms: 58 records
GO Description Category LogP Number of genes Detail
GO:0001508 action potential GO Biological Processes -2.21965331 5 More
GO:0002027 regulation of heart rate GO Biological Processes -9.97103962 23 More
GO:0003012 muscle system process GO Biological Processes -27.3938503 63 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003015 heart process GO Biological Processes -12.3962712 26 More
GO:0005261 cation channel activity GO Molecular Functions -1.68739377 23 More
GO:0006813 potassium ion transport GO Biological Processes -2.38043550 7 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008016 regulation of heart contraction GO Biological Processes -27.6827716 55 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0030001 metal ion transport GO Biological Processes -7.54203733 26 More
GO:0030029 actin filament-based process GO Biological Processes -9.62516039 61 More
GO:0031625 ubiquitin protein ligase binding GO Molecular Functions -1.82192201 21 More
GO:0034702 ion channel complex GO Cellular Components -2.54472403 10 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034763 negative regulation of transmembrane transport GO Biological Processes -22.14661 42 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0034767 positive regulation of ion transmembrane transport GO Biological Processes -11.2867591 18 More
GO:0035637 multicellular organismal signaling GO Biological Processes -4.89020616 9 More
GO:0042391 regulation of membrane potential GO Biological Processes -15.0641346 59 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043266 regulation of potassium ion transport GO Biological Processes -7.37974754 20 More
GO:0043267 negative regulation of potassium ion transport GO Biological Processes -7.26795046 12 More
GO:0043268 positive regulation of potassium ion transport GO Biological Processes -3.46605627 5 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0043271 negative regulation of ion transport GO Biological Processes -19.3914052 40 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0050801 ion homeostasis GO Biological Processes -12.0812968 60 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051899 membrane depolarization GO Biological Processes -3.15848951 8 More
GO:0055067 monovalent inorganic cation homeostasis GO Biological Processes -2.09308401 6 More
GO:0060047 heart contraction GO Biological Processes -8.83781505 20 More
GO:0060048 cardiac muscle contraction GO Biological Processes -7.88412825 17 More
GO:0060306 regulation of membrane repolarization GO Biological Processes -5.46127869 10 More
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization GO Biological Processes -2.50427121 3 More
GO:0061337 cardiac conduction GO Biological Processes -5.79383245 8 More
GO:0071466 cellular response to xenobiotic stimulus GO Biological Processes -9.33788411 28 More
GO:0086091 regulation of heart rate by cardiac conduction GO Biological Processes -2.81707928 4 More
GO:0097110 scaffold protein binding GO Molecular Functions -3.84008123 6 More
GO:0098655 cation transmembrane transport GO Biological Processes -3.98966777 20 More
GO:0098657 import into cell GO Biological Processes -2.13294972 7 More
GO:0098659 inorganic cation import across plasma membrane GO Biological Processes -1.65407437 9 More
GO:0098660 inorganic ion transmembrane transport GO Biological Processes -4.47276690 21 More
GO:0098662 inorganic cation transmembrane transport GO Biological Processes -4.65654157 20 More
GO:0098739 import across plasma membrane GO Biological Processes -1.45340005 5 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:0099587 inorganic ion import across plasma membrane GO Biological Processes -1.65407437 9 More
GO:0099623 regulation of cardiac muscle cell membrane repolarization GO Biological Processes -3.70345918 7 More
GO:0140115 export across plasma membrane GO Biological Processes -3.24021630 5 More
GO:0140352 export from cell GO Biological Processes -8.94733589 48 More
GO:1902495 transmembrane transporter complex GO Cellular Components -2.24412383 11 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:1904064 positive regulation of cation transmembrane transport GO Biological Processes -10.8655330 17 More
Drug-Gene interaction
view
Related drugs: 337 records
Drug name Interaction type Source PMID View
(-)-u-50488 methane sulfonate DTC view
4-nonylphenol DTC view
5-(n-methyl-n-isobutyl)amiloride DTC view
afimoxifene DTC view
alemcinal TTD view
alprenolol hydrochloride DTC view
amiodarone inhibitor TdgClinicalTrialTENDPharmGKB 147544221860422911997281117523521499911318505444 view
amiodarone hydrochloride DTC view
amitriptyline hydrochloride DTC view
amoxapine DTC view
amperozide hydrochloride DTC view
amsacrine hydrochloride DTC view
aptiganel hydrochloride DTC view
astemizole blockerinhibitor PharmGKB 103769211042279018701618104442351571816416253929149991131157500815272206 view
bemesetron DTC view
benoxathian hydrochloride DTC view
benzamil hydrochloride DTC view
benzethonium chloride DTC view
benztropine mesylate DTC view
benzyl salicylate DTC view
bmy-7378 DTC view
bp-897 DTC view
bromoenol lactone DTC view
budiodarone TdgClinicalTrial view
buspirone hydrochloride DTC view
butaclamol hydrochloride DTC view
calcimycin DTC view
calmidazolium chloride DTC view
captan DTC view
carbetapentane citrate DTC view
chembl106525 DTC view
chembl1079460 DTC view
chembl10835 DTC view
chembl1237255 DTC view
chembl1255966 DTC view
chembl1256647 DTC view
chembl1256660 DTC view
chembl1256663 DTC view
chembl1256689 DTC view
chembl1256726 DTC view
chembl1256735 DTC view
chembl1256754 DTC view
chembl1256797 DTC view
chembl1256998 DTC view
chembl1257031 DTC view
chembl1257083 DTC view
chembl1315166 DTC view
chembl1369632 DTC view
chembl1437888 DTC view
chembl1623028 DTC view
chembl1623897 DTC view
chembl1740701 DTC view
chembl180672 DTC 19625189 view
chembl2028044 DTC view
chembl2028045 DTC view
chembl2028050 DTC view
chembl2028056 DTC view
chembl2028063 DTC view
chembl2028066 DTC view
chembl2028068 DTC view
chembl26138 DTC view
chembl261693 DTC view
chembl27006 DTC view
chembl288174 DTC view
chembl317364 DTC view
chembl333121 DTC view
chembl344127 DTC view
chembl406931 DTC 17693551 view
chembl445102 DTC view
chembl49055 DTC view
chembl494669 DTC view
chembl524930 DTC view
chembl525106 DTC view
chembl525486 DTC view
chembl525519 DTC view
chembl525826 DTC view
chembl526981 DTC view
chembl527730 DTC view
chembl528245 DTC view
chembl529348 DTC view
chembl529640 DTC view
chembl529984 DTC view
chembl530149 DTC view
chembl531611 DTC view
chembl532141 DTC view
chembl532510 DTC view
chembl532525 DTC view
chembl533399 DTC view
chembl533921 DTC view
chembl534084 DTC view
chembl534319 DTC view
chembl535730 DTC view
chembl537087 DTC view
chembl538542 DTC view
chembl541585 DTC view
chembl543557 DTC view
chembl544115 DTC view
chembl545880 DTC view
chembl546168 DTC view
chembl546531 DTC view
chembl547269 DTC view
chembl547483 DTC view
chembl547488 DTC view
chembl548338 DTC view
chembl548469 DTC view
chembl549208 DTC view
chembl549216 DTC view
chembl553503 DTC view
chembl56543 DTC view
chembl577014 DTC view
chembl578294 DTC view
chembl579105 DTC view
chembl579315 DTC view
chembl580140 DTC view
chembl580159 DTC view
chembl580353 DTC view
chembl580516 DTC view
chembl581187 DTC view
chembl581194 DTC view
chembl581240 DTC view
chembl582180 DTC view
chembl582486 DTC view
chembl582666 DTC view
chembl582767 DTC view
chembl583555 DTC view
chembl584235 DTC view
chembl584655 DTC view
chembl584829 DTC view
chembl584841 DTC view
chembl585243 DTC view
chembl585686 DTC view
chembl585966 DTC view
chembl586026 DTC view
chembl586033 DTC view
chembl586344 DTC view
chembl586962 DTC view
chembl587892 DTC view
chembl587923 DTC view
chembl588501 DTC view
chembl589723 DTC view
chembl589920 DTC view
chembl589922 DTC view
chembl589946 DTC view
chembl590201 DTC view
chembl590212 DTC view
chembl590674 DTC view
chembl590914 DTC view
chembl590919 DTC view
chembl590947 DTC view
chembl591641 DTC view
chembl591887 DTC view
chembl592044 DTC view
chembl592123 DTC view
chembl592332 DTC view
chembl592344 DTC view
chembl592786 DTC view
chembl597248 DTC view
chembl597857 DTC view
chembl598270 DTC 24224763 view
chembl598279 DTC view
chembl598369 DTC view
chembl600030 DTC view
chembl600374 DTC view
chembl601325 DTC view
chembl601492 DTC view
chembl601528 DTC view
chembl601534 DTC view
chembl601743 DTC view
chembl602312 DTC view
chembl602413 DTC view
chembl602552 DTC view
chembl602580 DTC view
chembl602940 DTC view
chembl603370 DTC view
chembl605003 DTC view
chembl606159 DTC view
chembl607308 DTC view
chembl608855 DTC view
chembl609628 DTC view
chembl64119 DTC view
chembl72365 DTC view
chloranil DTC view
chlorpheniramine maleate DTC view
chlorpromazine hydrochloride DTC view
cinnarizine DTC view
cipargamin TTD view
cisapride inhibitorblocker DTC 12209010159678769374794174083101926073410510456 view
citalopram hydrobromide DTC view
clomipramine hydrochloride DTC view
clorgyline hydrochloride DTC view
clotrimazole DTC view
cp-55940 DTC view
cyclobenzaprine hydrochloride DTC view
cyproheptadine hydrochloride DTC view
daph DTC view
daruisoline DTC 22974355 view
desipramine hydrochloride DTC view
desmetheylastemizole TTD view
dexbrompheniramine maleate DTC view
dexpropranolol hydrochloride DTC view
dichlorophen DTC view
dicofol DTC view
diphenhydramine hydrochloride DTC view
disopyramide inhibitorblocker DTCPharmGKB 1684281715272206 view
disopyramide phosphate DTC view
dobutamine hydrochloride DTC view
dofetilide blockerinhibitor TdgClinicalTrialTENDPharmGKB 106486471554876418701618948666711723241155222801116628310712445117523521169807514999113 view
domiphen bromide DTC view
domperidone DTC view
doxazosin mesylate DTC view
doxepin inhibitor PharmGKB 17560554 view
dronedarone inhibitor TdgClinicalTrialTEND 1789695923997577 view
droperidol PharmGKB 14999113 view
econazole nitrate DTC view
eliprodil DTC view
elliptecine DTC view
endrin DTC view
erythromycin inhibitor PharmGKB 1661416812065733244172411467467715324906 view
estradiol NCI 18440994 view
fenofibrate DTC view
fenoldopam bromide DTC view
flecainide acetate DTC view
flunarizine hydrochloride DTC view
fluoxetine inhibitor PharmGKB 118052151696704615272206 view
fluoxetine hydrochloride DTC view
fluphenazine hydrochloride DTC view
flupirtine maleate DTC view
fluspirilene DTC view
gentian violet DTC view
gr-127935 DTC view
grepafloxacin PharmGKB 157181641625392914999113 view
guanabenz acetate DTC view
haloperidol DTCPharmGKB 16278312 view
hydroxyzine inhibitor PharmGKB 2189219219057127 view
ibutilide blockerinhibitor TdgClinicalTrialTEND 174972531526601415926871116028201629187316076272 view
idarubicin DTC view
imipramine hydrochloride DTC view
iofetamine hydrochloride DTC view
isoliquiritigenin DTC view
isoquine TTD view
kepone DTC view
ketanserin tartrate DTC view
l-745870 DTC view
lidoflazine PharmGKB 157181641627831214999113 view
lobeline hydrochloride DTC view
loperamide hydrochloride DTC view
loxapine succinate DTC view
maprotiline hydrochloride DTC view
metergoline DTC view
methadone PharmGKB 1732999214999113 view
methapyrilene hydrochloride DTC view
methiothepin mesylate DTC view
methoxyverapamil hydrochloride DTC view
methylrosaniline DTC view
mibefradil PharmGKB 16253929 view
mibefradil dihydrochloride DTC view
mitotane DTC view
moxifloxacin NCIPharmGKB 1647441516614168 view
n-aminohexyl-5-chloro-1-napthalenesulfonamide hydrochloride DTC view
naloxone benzoylhydrazone DTC view
nerispirdine TTD view
nicardipine hydrochloride DTC view
nisoxetine hydrochloride DTC view
nitrendipine PharmGKB view
nomifensine maleate DTC view
nortriptyline hydrochloride DTC view
nylidrin hydrochloride DTC view
oleic acid DTC view
omarigliptin DTC 24660890 view
orphenadrine hydrochloride DTC view
oxatomide DTC view
oxybutynin chloride DTC view
oxymetazoline hydrochloride DTC view
paroxetine hydrochloride DTC view
pd-169316 DTC view
pergolide mesylate DTC view
perphenazine DTC view
phenolphthalein DTC view
phenoxybenzamine hydrochloride DTC view
phentolamine mesylate DTC view
phenylmercuric acetate DTC view
pimozide inhibitor DTC 11377395115110861129655110762666 view
pirenperone DTC view
prenylamine PharmGKB 16278312 view
proadifen hydrochloride DTC view
probucol PharmGKB 15043509 view
promazine hydrochloride DTC view
propafenone inhibitor TdgClinicalTrialTENDPharmGKB 11330342126182281627831211752352 view
propafenone hydrochloride DTC view
propionylpromazine hydrochloride DTC view
propofol NCI 16368812 view
pyrilamine DTCPharmGKB 16278312 view
pyrilamine maleate DTC view
pyrithione zinc DTC view
pyrrolidine dithiocarbamic acid, ammonium salt DTC view
quinacrine dihydrochloride DTC view
quinidine inhibitor DTCPharmGKB 10028924158218401684281718582585156733881604119615125690 view
raloxifene hydrochloride DTC view
reserpine DTC view
retinol DTC view
risperidone DTC view
ritanserin DTC view
ropinirole hydrochloride DTC view
salmeterol xinafoate DTC view
saquinavir mesylate DTC view
sb-216763 DTC view
sb-224289 DTC view
semaxanib DTC view
sertindole inhibitor TdgClinicalTrialPharmGKB 15718164116891321627831211511086149991139694935 view
sertraline hydrochloride DTC view
skf-38393 DTC view
sotalol inhibitor TdgClinicalTrialTEND 1668668510931813156733881109054616076272 view
sotalol hydrochloride DTC view
spiperone hydrochloride DTC view
spiroxatrine DTC view
sulpiride DTC view
tamoxifen citrate DTC view
telithromycin PharmGKB 1661416816278312 view
terfenadine blockerinhibitor DTCPharmGKB 18701618157181641625392915102940117523521499911320636881 view
terodiline PharmGKB 157181641625392914999113 view
thioridazine inhibitor PharmGKB 1627831217056009 view
thioridazine hydrochloride DTC view
thiram DTC view
trazodone hydrochloride DTC view
trifluoperazine hydrochloride DTC view
trifluperidol hydrochloride DTC view
triflupromazine hydrochloride DTC view
triprolidine hydrochloride DTC view
tyrphostin ag 879 DTC view
vanoxerine DTC view
verapamil hydrochloride DTC view
vesnarinone TTD view
vinpocetine DTC view
win-552122 DTC view
yohimbine hydrochloride DTC view
zimelidine dihydrochloride DTC view
ziram DTC view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NM_000238.4:c.2690A>C genomics ventricular tachycardia[prognosis (bad)] acute myocardial infarction Crotti L et al. Heart Rhythm. 2012
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